Ificipro is a synthetic 4-quinolone derivative with bactericidal activity against a wide range of gram-positive and gram-negative organism. It is active against most gram-negative aerobic bacteria including Enterobacteriaceae and Pseudomonas aeruginosa. Ificipro is also active against gram-positive aerobic bacteria including penicillinase producing, non-penicillinase producing and methicillin resistant Staphylococci. However many strains of Streptococci are relatively resistant to the drug. The bactericidal activity of Ificipro results from interference with the enzyme DNA gyrase needed for the synthesis of bacterial DNA. The mode of action of Ificipro is different from other antibiotics like penicillins, cephalosporins, aminoglycosides, tetracyclines and for this reason it is observed that organisms resistant to these antibiotics are susceptible to Ificipro. Ificipro is well absorbed from the GIT after oral administration and it is widely distributed into the body tissues and fluid. The half-life of Ificipro is 3.5 - 4.5 hours. About 30-50% of an oral dose of Ificipro is excreted in the urine within 24 hours as unchanged drug and active metabolites.
