Elyzol, a nitroimidazole has an extremely broad spectrum antiprotozoal and antimicrobial activities, with high activity against anaerobic bacteria and protozoa. elyzol is usually completely and rapidly absorbed after oral administration. The half-life in plasma is about 8 hours. About 10% of the drug is bound to plasma proteins. elyzol penetrates well into body tissues and fluids. The liver is the main site of metabolism. Both unchanged elyzol and metabolites are excreted in various proportions in the urine after oral administration. elyzol treats amebiasis, trichomoniasis, and giardiasis, exerting both antibacterial and antiprotozoal activities. elyzol is an effective treatment for some anaerobic bacterial infections. elyzol has shown antibacterial activity against the majority of obligate anaerobes, however, during in vitro studies, it does not demonstrate significant action against facultative anaerobes or obligate aerobes. The nitro group reduction of metronidazole by anaerobic organisms is likely responsible for the drug's antimicrobial cytotoxic effects, causing DNA strand damage to microbes.
